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Posted Monday April, 12th 2021

Targeting the Autonomic Nervous System Balance in Patients with Chronic Low Back Pain Using Transcranial Alternating Current Stimulation: A Randomized, Crossover, Double-Blind, Placebo-Controlled Pilot Study

By Julianna H Prim,1–3,* Sangtae Ahn,1,2,* Maria I Davila,1 Morgan L Alexander,1,2 Karen L McCulloch,3,4,* Flavio Fröhlich1,2,5–8,*

Chronic pain is a severe, disabling condition that affects 25–30% of the population in the United States1 and treatment options are limited.2 While opioid therapy has shown short-term efficacy in decreasing pain, few studies have investigated its long-term effectiveness3 and systematic reviews identify multiple severe risks of long-term use including: misuse, abuse/dependence, overdose, and death.3,4 Chronic low back pain (CLBP) is the second most prevalent cause of disability in adults in the US.5 The poor rates of recovery (58% at 1 month) and high rates of recurrence (73% in 12 months) contribute to high social and economic costs.6

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