The default-mode network (DMN) and salience network (SN) have been shown to display altered connectivity in posttraumatic stress disorder (PTSD). Restoring aberrant connectivity within these networks with electroencephalogram neurofeedback (EEG-NFB) has been shown previously to be associated with acute decreases in symptoms. Here, we conducted a double-blind, sham-controlled randomized trial of alpha-rhythm EEG-NFB in participants with PTSD (n = 36) over 20-weeks. Our aim was to provide mechanistic evidence underlying clinical improvements by examining changes in network connectivity via fMRI.
• Double-blind, randomized, sham-controlled clinical trial of alpha-rhythm NFB.
• PTSD severity decreased in the experimental group only, comparison to sham ns.
• Evidence of normalized of DMN and SN connectivity post-treatment.
• Decreased PTSD severity and NFB performance correlated to SN and DMN changes.
• After treatment, 61.1% of experimental group no longer met criteria for PTSD.
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